Abstract: Background: Experimental Endoscopic Mucosal Resection (EMR) is a relatively new therapeutic method for resection of certain neoplastic lesions throughout the gastrointestinal (GI) tract in the veterinary practice. Materials and Methods: This experimental study was applied on five mongrel dogs to evaluate the technical efficacy and possible complications of such technique as well as using canine model for educational training of EMR technique. The range of resected mucosal size was 10-25×5-20 mm with surgical time range 32-61 min. Results: In the first three cases (with smaller resected mucosal sizes 15×10, 10×5 and 10×10 mm, respectively), there were no recorded complications. The fourth and fifth cases (with larger resected mucosal sizes 25×20 and 20×15 mm, respectively) showed postoperative vomiting. Conclusion: The present results were without complications such as bleeding or perforation as recorded in previous studies for human. The obtained results might be due to the application of suction followed by banding ligation.