Abstract: The objective of this study was to evaluate effects of various dietary concentrations of capsulated zinc oxide (C-ZnO) on growth performance, blood metabolism and mineral concentrations in weaning piglets. In this study, a total of 144 crossbred piglets (DurocxLandrancexYorkshire) were randomly assigned into 6 groups. One of six treatments was fed the basal diet supplemented with 0 (the control), 281.25, 562.5, 1125 and 2250 mg kg-1 zinc as C-ZnO and 2250 mg kg-1 zinc as zinc oxide (ZnO) for 21 days. Results indicated that compared to the control, dietary supplementation of C-ZnO (≥562.5 mg kg-1 zinc) and ZnO (2250 mg kg-1 zinc) increased (p<0.05) the average daily gain, decreased (p<0.05) the feed: gain ratio as well as serum urea nitrogen concentration. Lower levels of zinc as C-ZnO (281.25-1125 mg kg-1 zinc) decreased (p<0.05) the zinc concentrations in liver, kidney and feces compared with 2250 mg kg-1 zinc as ZnO. These results showed that lower levels (281.25-1125 mg kg-1) of zinc as C-ZnO enhanced growth performance, altered blood metabolism and decreased fecal zinc excretion in weaning piglets compared to pharmacological concentration of zinc as ZnO.