Abstract: The objective of this study was to study in detail about the endocrine cells of the camel duodenum. The duodenum is not only an important part of the gastrointestinal tract, but also works as endocrine portion by secreting some hormones that play key roles in the regulation of certain organs. Specimens from eleven dromedarian camels (Camelus dromedarius) of both sexes with age ranging from 2-12 years were examined. The immunohistochemistry was performed using five types of hormones. Gastrin showed high immunoreactivity at the endocrine of tunica mucosa and duodenal glands. Somatostatin showed very high immunoreactivity at endocrine of tunica mucosa and duodenal gland. The performance of insulin, which was done for the first time on the duodenum of camel, showed low immunoreactivity at endocrine cells of tunica mucosa and duodenal glands. Serotonin showed high immunoreactivity at the enteroendocrine cells of the tunica mucosa and few cells that produced serotonin at duodenal glands. Glucagon showed moderate to low immunoreactivity at the endocrine of tunica mucosa and duodenal glands. In conclusion, the study results found that the duodenum of the camel has distinctive characters immunohistochemically. Therefore, further physiological and experimental studies are required.