Abstract: A study was carried out to determine the effects of varying levels of whole cottonseed on feed intake, weight gain and blood parameters in FriesianxBunaji and Bunaji heifers. Twenty FriesianxBunaji and 24 Bunaji pre-pubertal heifers were divided to 4 groups of 5 and 6 animals/group. Animals in each group were fed 1 of 4 experimental concentrate diets containing 0, 25, 50 and 75% whole cottonseed for 140 days. The result of the study showed that concentrate intake declined with increase in the level of whole cottonseed in dieting averaging 4.2, 3.3, 3.1 and 2.9 kg head -1day -1 in FriesianxBunaji fed 0, 25, 50 and 75% whole cottonseed diets, respectively. The corresponding intake figures for the Bunaji heifers were 3.1, 2.9, 2.5 and 2.2 kg head -1 day -1. Mean daily weight gain were 0.59, 0.59, 0.48 and 0.64 kg in FriesianxBunaji and 0.48, 0.41 and 0.50 C kg in Bunaji heifers fed 0, 25, 50 and 75% whole cottonseed levels, respectively. Changes in blood parameters were not significant in both FriesianxBunaji and Bunaji heifers across treatments. The study showed that heifers could be fed diets containing up to 75% whole cottonseed, respectively without adverse effects.