Abstract: Background and Objective: Lophira lanceolata and Alchornea cordifolia are plants used for the treatment and management of perimenopausal, menopausal and menstrual cycle disorders, with claims of high efficacies by users. This study aimed at assessing fertility hormones of menopausal rats after the administration of the herbs. Materials and Methods: Twenty-five female albino wistar rats divided into Groups A, C, D and E consisting of irregularly cycling menopausal rats and Group B consisting of young regularly cycling rats were used for this study. Groups A and B served as negative and positive control respectively while Groups C, D and E were the experimental groups. Extract administration to the treated groups was for 21 days and animals were sacrificed on the 22nd day (pro-oestrus phase). Blood sample was collected for hormone assay and pituitary glands were dissected out for tissue processing. Results: Statistical analysis of level of serum oestradiol in groups B, C and D showed a significant increase (p<0.05) with the combined extract group recording the highest when compared to the negative control. The value of FSH in combined extract treated group was lower but not statistically significant at p<0.05 when compared with the negative control. Progesterone, LH and testosterone level was not significantly different (p<0.05) among the groups. Cells of the pituitary gland were normal. Conclusion: The findings of this study demonstrate that hormone pattern for the combined extract-treated group was similar to that of positive control. Therefore, combined leaf extracts of these herbs may be useful in the management of sub-fertility associated with peri-menopause and menopause.