Abstract: Background and Objective: Guar korma meal (Cyamopsis tetragonoloba) is one of some nutritional sources of feed proteins which contain high protein, approximately 50% or more. This study aimed to evaluate the effect of using Guar Korma Meal (GKM) as a new source of protein in rations on productive performance for Egyptian buffalos. Materials and Methods: The first trial was carried out to determine the in vitro disappearance gas production of dry and organic matter (IVDMD and IVOMD) of the different experimental Concentrate Feed Mixtures (CFM) containing different levels of GKM instead of Sunflower Meal (SM). The second trial, depending on the results of first experiment 20 buffalos averaging 450 kg Live Body Weight (LBW) were chosen into four similar groups in the same lactation season. Animal groups were receive four experimental rations containing CFM which included GKM at the rate of 0, 6, 8 and 10% in rations R1, R2, R3 and R4 replacement with SM. Results: The results obtained from the first experiment revealed that the IVDMD and IVOMD in gas production increased with increasing the replacement level of GKM in concentrate feed mixture. The second experiment indicated that the digestibility of Dry Matter (DM), Organic Matter (OM), Crude Protein (CP) and nutritive value expressed as Total Digestible Nutrients (TDN) increased (p<0.05) with increasing the replacement level of GKM in the rations. Average actual milk and Fat Corrected Milk (FCM) yield were increasing with increasing level of GKM. Blood parameters were within normal range and improve lipid profile. Average feed cost per kilogram milk yield decreased with increasing GKM levels. Conclusion: Conclusively, it could be recommended that substitution SM by GKM in Egyptian buffalo’s rations seems to be the best for the digestibility, improve lipid profile and productive performance.