Abstract: Background and Objective: The regional distribution and relative frequency of gastrointestinal endocrine cells has been found to vary with the animal species and feeding habits. This study aimed to analyze the existence and distribution of immunoreactive endocrine cells to chromogranin, ghrelin, somatostatin, serotonin and gastrin in the gastric mucosa of sunda porcupine (Hystrix javanica ) using immunohistochemistry. Materials and Methods: Five adult sunda porcupines were used without sexual distinction. The presences of endocrine cells were visualized by ABC immunohistochemical methods using five types of polyclonal antisera, specific for chromogranin, ghrelin, somatostatin, serotonin and gastrin. Results: In the stomach of sunda porcupine, endocrine cells immunoreactive for all of these markers were observed. The chromogranin-immunoreactive cells were found with greatest frequency, in all stomach regions. In all regions of the stomach, endocrine cells secreting ghrelin were also detected in weaker frequency compare with chromogranin. The somatostatin immunoreactive cells were detected rare in the gastric and fundic regions, serotonin cells were found rare in fundic but few in pyloric regions, while gastrin cells were detected abundance in pyloric region of stomach of the sunda porcupines. Gastrin positive cell was also detected in the duodenal part of sunda porcupine. The chromogranin-positive cells were the most numerous, being more prevalent in the stomach glands. The other endocrine cells were identified in smaller numbers, some of them located in all regions or in specific regions. The finding of these cell types in the mucosal stomach confirms their preferential location in the final portions of the principal regions of the stomach and suggests control by feedback of its functions. Conclusion: In conclusion, the present study show for the first time the immunolocalization of chromogranin, ghrelin and gastrin immunoreactive cells in the stomach of sunda porcupine. However, in contrast with previous finding of crested porcupine and other rodents, the present result found serotonin immunoreactive cells in the fundic and pyloric gland regions and somatostatin immunoreactive cells in the gastric and fundic gland regions of sunda porcupine stomach. The differences may was caused by feed types, feeding habits and geographical locations of the species.