Abstract: Contagious caprine pleuropneumonia caused by Mycoplasma capricolum subspecies capripneumoniae is a highly contagious and serious respiratory disease of domestic goats, characterized by coughing, severe respiratory distress and high mortality rates. There is dearth of well documented information on the occurrence of contagious caprine pleuropneumonia among goats in Jijiga zone, Ethiopia. Therefore, this study was designed with the aims to determine the seroprevalence of caprine pleuropneumonia in the selected districts of Jijiga zone and to assess potential risk factors on the occurrence of the disease. Cross-sectional study design was conducted from November 2011 to March 2012 among selected districts of Jijiga zone namely Jijiga, Kebri Beyah and Tuli Guled districts. A total of 334 goat sera were examined for the presence of specific antibodies against Mycoplasma capricolum subspecies capripneumoniae using complement fixation test. Proportions and chi square test statistics were used to analyze the data. District, sex and age of the goats were considered to be the major risk factors for the occurrence of contagious caprine pleuropneumonia. The overall seroprevalence of contagious caprine pleuropneumonia in Jijiga zone was proved to be 32.63%. The seroprevalence of contagious caprine pleuropneumonia at District level was confirmed to be 34, 33.64 and 28.38% in Jijiga, Kebri Beyah and Tuli Guled districts, respectively. The result indicated that there was no statistical significant difference (p>0.05) on seropositivity among the three districts and between the two sex of goats examined in this research. Age was found to be significantly associated (p<0.05) with the prevalence of contagious caprine pleuropneumonia in goats. In conclusion the present study indicated that the overall prevalence of contagious caprine pleuropneumonia in Jijiga zone was high and underlines the importance of further epidemiological study of the disease and its associated risk factors and implementation of appropriate preventive and control measures. Besides to this finding suggests the need to implement strict awareness creation among goat owners on vaccination of their animals in order to decrease the prevalence of contagious caprine pleuropneumonia in Jijiga, Kebri Beyah and Tuli Guled districts.