Abstract: The field experiment was carried out at the University of Cape Coast Research Farm, Cape Coast, Ghana, from August, 2014 to February, 2015. The objectives of the study were to determine the effects of deficit irrigation-chicken manure interactions, deficit irrigation-NPK interactions and compare the results of deficit irrigation-chicken manure and deficit irrigation-NPK. Fifteen (15) treatments replicated three (3) times were laid out in a Randomized Complete Block Design (RCBD). The 15 treatments were 100% Crop Water Requirement (CWR); (T1) 90% CWR, (T2) 80% CWR, (T3) 100% CWR+5 t ha–1 chicken manure, (T4) 100% CWR+10 t ha–1 chicken manure, (T5) 90% CWR+5 t ha–1 chicken manure, (T6) 90% CWR+10 t ha–1 chicken manure, (T7) 80% CWR+5 t ha–1 chicken manure, (T8) 80% CWR+10 t ha–1 chicken manure, (T9) 100% CWR+200 kg ha–1 NPK 15:15:15, (T10) 100% CWR+250 kg ha–1 NPK, (T11) 90% CWR+200 kg ha–1 NPK, (T12) 90% CWR+250 kg ha–1 NPK, (T13) 80% CWR+200 kg ha–1 NPK, (T14) and 80% CWR+250 kg ha–1 NPK (T15). Deficit irrigation-chicken manure performed better than deficit irrigation-NPK at 100% CWR and 90% CWR. The 20% deficit irrigation plus high doses of chicken manure and NPK performed poorly. The 10% deficit irrigation with 10 t ha–1 chicken manure and 250 kg ha–1 NPK are best for okra production.