Abstract: Phyllanthus buxifolius is an herbal plant, which is known to have antilipidemic and anticholesterolemic effects. The aim of this study was to explore the effects of leaf powder P. buxifolius supplementation in broiler feed on intracellular lipid accumulation, serum leptin and meat cholesterol levels. Sixty broiler chickens aged at 22 days were divided into two treatment groups. The first group was fed commercial feed without powdered leaves of P. buxifolius (control) and another group was fed commercial feed with 5% powdered leaves of P. buxifolius. The results showed that the accumulation of intracellular lipids, serum leptin levels, fat and cholesterol of meat and abdominal fat weight of chickens fed 5% powdered leaf P. buxifolius in feed were significantly lower than those fed the control diet. It can be concluded that administration of 5% powdered leaf P. buxifolius in broiler feed capable of lowering intracellular accumulation of lipids, serum leptin levels, fat and cholesterol of meat and abdominal fat weight.