Abstract: Background and Objective: The housefly species are found in human habitations and refuse dumpsites. The housefly is a notable pest in animal production facilities. The study evaluated the effect of temperature gradient on the survival and mortality of the developmental and adult stages of the housefly, Musca domestica. This is intended to determine the effect of temperature variations on the development of egg, larva, pupa and survival of the adult M. domestica. Materials and Methods: The immature stages produced by the adults of the flies were separately exposed to 15.6, 22.2, 28.8, 32.2 and 36.1°C, using SPX-II biochemical incubator. Twenty of each of the developmental stages was exposed to the different temperatures in four replicates. Adult males and females of ages 0, 5, 10, 15 and 20 days were divided into batches (n = 20) and incubated for 8 hrs and further monitored for 72 hrs in the laboratory. Results: Temperature has a significant effect on the development of the eggs, larvae and pupae, the development of the immature stages was highest at 28.8 and 32.2°C but lowest at 36.1°C. Adult emergence was highest under 28.8°C and lowest under 36.1°C. Temperature significantly (p<0.05) affected the survival of adults, irrespective of their age. Adult survival was highest under 22.2°C and lowest under 36.1°C and females have higher survival than males under the same temperature. Conclusion: Based on the developmental and survival data obtained, temperature variation can be used as an effective means to control the population of both developmental and adult stages of M. domestica.