Abstract: Background and Objective: Several variables involved in favoring the Zoonotic Cutaneous Leishmaniasis (ZCL) occurrence at local scale were categorized and integrated in a new Cutaneous Leishmaniasis Vulnerability Index. The main objective was to test its applicability and explore which sector(s), site(s) or factor(s) presenting the high vulnerability regarding this disease. Materials and Methods: This proposed index was a numerical tool conglomerating and categorizing five components of variables that may accelerating the vulnerability to this disease, socio-economical, climatic, hydraulic, vegetation and health. The calculations were applied in four case studies from the Moroccan arid region. Results: This Index gave a lot of information in a single profile of the local vulnerability. All the selected sites had high vulnerability scores to this disease. Agdez presened the very high score of vulnerability than the rest, Tamezmoute, Zagora and Tagonite following an upstream-downstream evolution. Conclusion: The findings gave a scientific basis, which is helpful for the decision making regarding the control and surveillance in an arid region at a local scale.