Abstract: The present study was carried out to determine the effect of scorpion Mesobuthus tamulus gangeticus Pocock (Family: Buthidae) venom on different blood parameters in albino mice (NIH strain). Venom was isolated by electric stimulation and its toxicity was determined in albino mice by subcutaneous envenomation. Median lethal dose of scorpion M. tamulus gangeticus venom was 2.5 mg kg-1 b.wt. of mice. Effect of scorpion M. tamulus gangeticus venom on red blood cell count, blood haemoglobin, mean corpuscular haemoglobin, white blood cell count, packed cell volume and plasma haemoglobin was determined in albino mice. Mesobuthus tamulus gangeticus venom caused significant reduction in red blood cell count and significant increase in blood haemoglobin, mean corpuscular haemoglobin, white blood cell count, packed cell volume and plasma haemoglobin in dose and time-dependent manner. In vitro pre-incubation of red blood cells with M. tamulus gangeticus venom caused fragility of red blood cells in concentration-dependent manner. It was concluded that these haematological changes after envenomation were due to the haemolytic property of scorpion M. tamulus gangeticus venom.