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Trends in Medical Research
  Year: 2017 | Volume: 12 | Issue: 2 | Page No.: 65-70
DOI: 10.3923/tmr.2017.65.70
 
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Light Microscope Study of Intratympanic Methylprednisolone Effect on Cisplatin Induced Ototoxicity
Abdul Qadar Punagi, Ahmad Ardhani Pratama, Abdul Kadir, Eka Savitri and Andi Nilawati Usman

Abstract:
Background and Objective: The use of intratympanic methylprednisolone has a significant effect on the improvement of the cochlear response. This research aimed to study the histologic imaging of the effect of intratympanic methylprednisolone on ototoxicity induced cisplatin. This research aimed to examine the histologic imaging of the effect of intratympanic methylprednisolone on ototoxicity induced cisplatin. Materials and Methods: This is an experimental study with pre-post test control group design. Data obtained from 11 New Zealand strain rabbits, were treated with 4.6 mg kg–1 cisplatin intraperitoneal followed by the treatment of 0.5 mg kg–1 intratympanic methylprednisolone. They underwent distortion product evoked otoacoustic emission testing at baseline, at day 3 and 9. At the day 3 and 9 of the experiment, the animals were sacrificed and their cochlear were retrieved and prepared for hematoxylin and eosin staining. The histopathologic changes that occurred were observed based on the scoring system. The difference of cochlear damage analyzed statistically with Independent sample by t-test. Results: Assessment of cochlear damage by the degree of stria vascular damage by using a scoring system, as indicated by the level of shrinkage of the intermediate cells. There is a difference of cochlear damage (stria vascularis) on day 9 of cisplatin administration between group 1 (cisplatin) and group 2 (cisplatin+methylprednisolone) (p<0.026). There is a difference in cochlear damage (stria vascularis) between day 3 and 9 in group 2 (cisplatin+methylprednisolone) but not statistically significant (p>0.05). Conclusion: Histologically, intratympanic methylprednisolone giving effect to the improvement of cochlear function.
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How to cite this article:

Abdul Qadar Punagi, Ahmad Ardhani Pratama, Abdul Kadir, Eka Savitri and Andi Nilawati Usman, 2017. Light Microscope Study of Intratympanic Methylprednisolone Effect on Cisplatin Induced Ototoxicity. Trends in Medical Research, 12: 65-70.

DOI: 10.3923/tmr.2017.65.70

URL: https://scialert.net/abstract/?doi=tmr.2017.65.70

 
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