Abstract: Background: Large cervical thyroid gland usually represented a challenge facing the general surgeon. It usually difficult in performance need higher curve of skill and complications usually unavoidable. Objective: Researcher presented a technique modification rendering total thyroidectomy for large cervical thyroid an easy procedure, with short operative time and high safety. Materials and Methods: The present study included 25 patients for elective thyroidectomy for large thyroid goiter. The surgical indication was bilateral multi-nodular goiter. All patients were evaluated preoperatively and postoperatively. Postoperative complications were documented and postoperative pain was evaluated using a Visual Analogue Scale (VAS). Results: Females represented 72% of studied subjects, there was statistically significant decrease of postoperative calcium and parathyroid hormone (PTH) when compared to corresponding preoperative values (9.58±0.29 and 53.32±4.91 vs. 9.13±0.40 and 32.80±5.84, respectively). The operative time ranged from 66-90 min with a mean of 73.88±5.31 min, the amount of drainage at 24 h postoperatively ranged from 19-36 mL with a mean of 27.56±4.25 mL. In addition, there was statistically significant progressive decrease of pain from 5-24 h postoperatively. About 9 subjects (36.0%) needed analgesia at 6 h and 5 subjects (20.0%) needed analgesia at 18 h and no injury of recurrent laryngeal nerve injury was reported. Conclusion: Midline splitting dissections of each thyroid lobe provide an effective, extra-safe technique to removal of large thyroid gland.