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Trends in Medical Research
  Year: 2016 | Volume: 11 | Issue: 3 | Page No.: 88-94
DOI: 10.3923/tmr.2016.88.94
Intercellular Adhesion Molecule-1 in Early Diagnosis of Neonatal Infection
M.M. Elmazahi, S. Abd Rabou, M.Z. El-Ghannam, M.I. Abdel-Aal and F.M. Elries

Background: Infection is a leading cause of neonatal morbidity and mortality worldwide. Neonatal sepsis, defined as sepsis within the first 28 days of life is estimated to cause 26% of all neonatal deaths worldwide. Diagnosis of the neonatal Infection is difficult, C-reactive protein (CRP) is widely used as a marker of infection; however, its usefulness is limited in the early phase. The role of intracellular adhesion molecule-1 (ICAM-1) has been examined in recent studies as an early marker of neonatal infection with controversial results. Objective: The purposes of this study were to determine the usefulness of ICAM-1 in the early diagnosis of neonatal sepsis and the relation of its level to the clinical severity of the disease in comparison with other biomarkers before and after initiation of therapy. Methodology: The study consisted of 51 neonates who were chosen from NICU of Damietta General Hospital. The studied neonates were classified into 2 groups: (1) Cases group (n = 34): These were cases with suspected neonatal sepsis. This group was furtherly subdivided according to blood culture into two subgroups: (a) Infected group (n = 23): These were patients with positive blood culture, (b) Not infected group (n = 11): These were patients with negative blood culture. (2) Control group (n = 17): These were neonates who were apparently healthy with negative CRP and blood culture. Results: Among the study group and according to the results of blood culture, it was found 23 (68%) out of 34 of the studied neonates had neonatal infection. The mean ICAM-1 levels were found significantly high (415.3±165.3) in the study infected group of neonates (23 out of 34) in comparison with not infected study group (351.5±63.2) and control group (241.5±98.1). Conclusion: The ICAM-1 level is increased in neonatal infection and seems to be correlated with its severity. Assessment of ICAM-1, particularly the higher level could be a useful and early marker in neonatal sepsis and it could be used as good indicator of early neonatal infection while the CRP levels within normal range at the time of the sampling.
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How to cite this article:

M.M. Elmazahi, S. Abd Rabou, M.Z. El-Ghannam, M.I. Abdel-Aal and F.M. Elries, 2016. Intercellular Adhesion Molecule-1 in Early Diagnosis of Neonatal Infection. Trends in Medical Research, 11: 88-94.

DOI: 10.3923/tmr.2016.88.94








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