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Trends in Medical Research
  Year: 2016 | Volume: 11 | Issue: 2 | Page No.: 82-87
DOI: 10.3923/tmr.2016.82.87
 
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Curcumin Intake Could Lower Serum Macrophage Migration Inhibitory Factor and Monocyte Chemoattractant Protein-1 Levels in Obese Subjects

Nagwa Abdallah Ismail , Soha M. Abd El Dayem, Mona Hamed, Dina F. Ayoub, Eman Mahmoud Hassan and Heba Assal

Abstract:
Controlling of inflammatory process associated with obesity is a big challenge. Both Monocyte Chemoattractant Protein-1 (MCP-1) and macrophage Migration Inhibitory Factor (MIF) may play a role in this process. Aim to evaluate serum MPC-1 and MIF levels in obese subjects and detect the effect of oral curcumin intake. The study included 60 obese subjects (30 children and 30 adults). The trial subjects received a 500 mg curcumin capsule with the main meal for 4 weeks. Controls received a placebo capsule for 4 weeks. A total of 60 normal weights enrolled as controls. The MIF and MCP-1 levels were measured on days 1 and 29 using commercially available ELISA kits. The mean serum level of MPC-1 and MIF were significantly higher in obese group than in controls. Curcumin intake resulted in statistically significant decrease in serum MPC-1 and serum MIF in children and adults. Our results showed that curcumin could help in lowering MIF and MPC-1 associated with obesity. It could help in prevention of obesity complications.
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How to cite this article:

Nagwa Abdallah Ismail, Soha M. Abd El Dayem, Mona Hamed, Dina F. Ayoub, Eman Mahmoud Hassan and Heba Assal, 2016. Curcumin Intake Could Lower Serum Macrophage Migration Inhibitory Factor and Monocyte Chemoattractant Protein-1 Levels in Obese Subjects. Trends in Medical Research, 11: 82-87.

DOI: 10.3923/tmr.2016.82.87

URL: https://scialert.net/abstract/?doi=tmr.2016.82.87

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