Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Trends in Medical Research
  Year: 2015 | Volume: 10 | Issue: 4 | Page No.: 97-105
DOI: 10.3923/tmr.2015.97.105
Variations in Blood Parameters of High Salt Loaded Rats Following Administration of Moringa oleifera Leaf Extract
O.E. Ofem, E.J. Ani, A.N. Archibong and J.M. Ufford

Abstract:
High salt loading is associated with myriad deleterious effects including alterations in blood parameters, cardiovascular risk and sudden death. This study explored the impact of Moringa oleifera on some blood parameters in high salt loaded rats. Twenty four male albino Wistar rats were assigned into 4 groups of 6 rats each. They were fed on either control diet, high salt diet (8% NaCl diet+1% NaCl drinking water) and/or Moringa extract (600 mg kg–1 b.wt. orally, once daily) ad libitum for 6 weeks. Blood samples were obtained via cardiac puncture for full blood count measurement using automated blood counter. Results revealed that the high salt fed untreated rats had significant increases in their total WBC, RBC, platelet counts, PCV, lymphocytes, P-LCR, MPV and PDW. These increases were reversed to near control levels by Moringa. Also, Moringa reversed lowered, MCHC platelet and neutrophil counts in high salt loaded rats. Values obtained for control group include: RBC (7.02±0.16×106 cell μL–1), total WBC (8.08±0.80×103 cell μL–1), PCV (40.30±1.14%), platelet count (673.17±18.89×103 cell μL–1), RDW-SD (35.70±0.32 fL). In conclusion, Moringa oleifera extract prevents changes in total WBC, RBC count, packed cell volume (hematocrit), platelet count, lymphocytes, neutrophils, MPV, P-LCR and PDW in high salt fed rats, these parameters are determinants of the blood volume, hemostasis and the tendencies to excessive bleeding, cardiovascular diseases, hypertension and sudden death.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

O.E. Ofem, E.J. Ani, A.N. Archibong and J.M. Ufford, 2015. Variations in Blood Parameters of High Salt Loaded Rats Following Administration of Moringa oleifera Leaf Extract. Trends in Medical Research, 10: 97-105.

DOI: 10.3923/tmr.2015.97.105

URL: https://scialert.net/abstract/?doi=tmr.2015.97.105

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 

       

       

Curve Bottom