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Trends in Medical Research
  Year: 2015 | Volume: 10 | Issue: 3 | Page No.: 63-68
DOI: 10.3923/tmr.2015.63.68
Effect of Fasting on Intestinal Motility and Transit in Albino Wistar Rats
A.O. Obembe, V.E. Okon, E.O. Ofutet and R.A. Ayitu

Abstract:
Fasting is the act of willingly abstaining from some or all probable kinds of food, drinks or both for a period of time. Knowledge of the effect of fasting on intestinal motility and transit is incomprehensible, this study, therefore, seeks to ascertain the effect of fasting on intestinal motility and intestinal transit. Twelve albino wistar rats of body weight ranging between 160-200 g were used. These rats were randomly assigned into 2 groups, control and test (fasted) with six rats each. Both groups were fed with normal rodent chow and water for 30 days but the test groups were deprived of food for 12 h during the time frame (6 am-6 pm) of the experiment. The results obtained showed that fasting caused a significant decrease in intestinal motility compared to the control group on administration of atropine, a significant decrease in motility on administration of acetylcholine at the range of 9.56±0.74 and 32.03±0.78 μg mL–1, respectively for both control and the test groups. It was also determined that fasting did not cause any significant change in intestinal motility on administration of propranolol 387.50±24 and 387.50±141.97 μg mL–1, respectively and -737.50±87.50 and -420.83±24.88 μg mL–1, respectively, on administration of adrenaline. It was determined that fasting did not cause any significant change in intestinal transit (51.70±7.65 cm) and (40.74±7.14 cm), respectively in both groups. Conclusively, fasting reduces intestinal motility but has no significant effect on intestinal transit. Therefore, its use to enhance better well being and increased life’s expectancy is encouraged as may be beneficial to patients with spastic colitis and some other intestinal motility disorders. However, it must be done under proper supervision to avoid other gastrointestinal complications such as ulcers.
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How to cite this article:

A.O. Obembe, V.E. Okon, E.O. Ofutet and R.A. Ayitu, 2015. Effect of Fasting on Intestinal Motility and Transit in Albino Wistar Rats. Trends in Medical Research, 10: 63-68.

DOI: 10.3923/tmr.2015.63.68

URL: https://scialert.net/abstract/?doi=tmr.2015.63.68

 
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