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Trends in Medical Research
  Year: 2013 | Volume: 8 | Issue: 2 | Page No.: 36-62
DOI: 10.3923/tmr.2013.36.62
Protective Effect of Omega-3 Fatty Acids on 5-fluorouracil-induced Small Intestinal Damage in Rats: Histological and Histomorphometric Study
Salwa Aly Abou-Elez Gawish, Doria Ahmed Nosseir, Nesreen Moustafa Omar and Nahla Mohamed Reda Sarhan

Abstract:
Omega-3 fatty acids have a therapeutic role in many inflammatory conditions. The aim of the study, to investigate the protective effect of omega-3 fatty acids on 5-fluorouracil-induced small intestinal cytotoxicity. Fluorouracil (FU) and Omega group rats were given a single intraperitoneal injection of 5-fluorouracil (150 mg kg-1). Rats of the second group also received oral omega-3 (1 mL animal-1 day-1). Four rats from both FU subgroups (FU1, FU3, FU6 and FU9) and Omega subgroups (Omega1, Omega3, Omega6, Omega9) were sacrificed 1, 3, 6, 9 days after 5-fluorouracil injection. Histological, histomorphometric and statistical studies for small intestine were done. FU1 and FU3 subgroups demonstrated signs of mucositis such as separation of the epithelium and denudation of the villi. Histological signs of initial recovery appeared in FU6 and was followed by full recovery in FU9. Preserved structural integrity and faster recovery were observed in the Omega group. The conclusion of this study, omega-3 fatty acids ameliorate 5-fluorouracil-induced small intestinal damage.
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How to cite this article:

Salwa Aly Abou-Elez Gawish, Doria Ahmed Nosseir, Nesreen Moustafa Omar and Nahla Mohamed Reda Sarhan, 2013. Protective Effect of Omega-3 Fatty Acids on 5-fluorouracil-induced Small Intestinal Damage in Rats: Histological and Histomorphometric Study. Trends in Medical Research, 8: 36-62.

DOI: 10.3923/tmr.2013.36.62

URL: https://scialert.net/abstract/?doi=tmr.2013.36.62

 
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