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Trends in Medical Research
  Year: 2013 | Volume: 8 | Issue: 1 | Page No.: 16-26
DOI: 10.3923/tmr.2013.16.26
 
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Applicability of Biomarkers for Differentiation of Inverted Papilloma Assigned for Endoscopic Surgery

Mohammad M. Fatthy Ramadan, Ahmed Abd Elrahman Mahmoud, Ahmed M. Abdelhady Elsheikh and Hatem Salah Eldin Elhabashy

Abstract:
The aim of this study is to evaluate safety and feasibility of endoscopic surgery for management of nasal Inverted Papilloma (IP). The study estimated tissue extract Epidermal Growth Factor Receptor (EGFR) and serum Squamous Cell Carcinoma Antigen (SCCA) levels to determine their applicability for differentiation between different pathological entities of IP. All patients with IP underwent full history taking, general and local examination and CT imaging. Endoscopic biopsy was taken and then endoscopic excision was conducted under general anesthesia. Freshly excised IP were divided into two parts; the first for pathological examination and the second part was used for estimation of tissue extract level of EGFR. Venous blood samples were obtained before and after surgical resection for enzyme-linked immunosorbent assay (ELISA) estimation of serum SCCA. The study also included 10 healthy volunteers as a control group. The study included 19 IP patients; 9 patients had do novo IP, 6 patients had recurrent IP and 4 had IP with Squamous Cell Carcinoma (SCC) changes. All surgeries were conducted safely without complications within a mean operative time of 74.5±13.5 min, mean blood loss of 158.2±27.8 mL and mean postoperative duration of hospital stay of 5.4±1.3 days. Mean preoperative serum SCCA levels were significantly higher in IP patients compared to controls and in patients had IP with SCC compared to those had benign IP with non-significantly higher levels detected in sera of patients had recurrent IP compared to those had de novo IP. Postoperative serum levels of SCCA were significantly lower in all patients compared to their respective preoperative levels and non-significantly higher levels in patients had IP with SCC compared to those had benign IP. Mean tissue extract levels of EGFR were significantly higher in tissues of IP with SCC compared to tissues of benign IP with significantly higher tissue extract levels in recurrent IP compared to tissues of de novo IP. Functional endoscopic surgery could be considered as safe and effective line of management of IP. Estimation of EGFR tissue expression level could be used for differentiation between benign IP and IP with malignant transformation even in early phases of dysplasia and serum SCCA could be used as a marker for complete operative excision of IP irrespective of its pathological diagnosis.
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How to cite this article:

Mohammad M. Fatthy Ramadan, Ahmed Abd Elrahman Mahmoud, Ahmed M. Abdelhady Elsheikh and Hatem Salah Eldin Elhabashy, 2013. Applicability of Biomarkers for Differentiation of Inverted Papilloma Assigned for Endoscopic Surgery. Trends in Medical Research, 8: 16-26.

DOI: 10.3923/tmr.2013.16.26

URL: https://scialert.net/abstract/?doi=tmr.2013.16.26

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