• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Trends in Medical Research
  2. Vol 3 (2), 2008
  3. 82-89
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Trends in Medical Research

Year: 2008 | Volume: 3 | Issue: 2 | Page No.: 82-89

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 399

Search


Authors


Moustapha Ouedraogo

Country: Belgium

Christophe S. Da

Country: Burkina Faso

Innocent S. Nacoulma

Country: Burkina Faso

Hamado Kafando

Country: Burkina Faso

Rasmane Semde

Country: Burkina Faso

Issa T. Some

Country: Burkina Faso

Rasmata Ouedraogo

Country: Burkina Faso

Innocent P. Guissou

Country: Burkina Faso

Brigitte Evrard

Country: Belgium

Viviane Henschel

Country: Belgium

Jacques Dubois

Country: Belgium

Karim Amighi

Country: Belgium

Keywords


  • chronic osteomyelitis
  • implant
  • monoolein
  • gentamicin
  • Clinical assessment
Research Article

Preliminary Clinical Assessment of a Gentamicin-Loaded Monoolein Gel Intended to Treat Chronic Osteomyelitis

Moustapha Ouedraogo, Christophe S. Da, Innocent S. Nacoulma, Hamado Kafando, Rasmane Semde, Issa T. Some, Rasmata Ouedraogo, Innocent P. Guissou, Brigitte Evrard, Viviane Henschel, Jacques Dubois and Karim Amighi
The aim of this current study was to perform a preliminary clinical assessment of efficacy and safety of a biodegradable gentamicin-loaded monoolein gel. An open single dose, one treatment study including 19 patients with chronic osteomyelitis caused by a microorganism sensitive to gentamicin was conducted. After surgical curettage of the infected bone, the dead space was filled in with the gentamicin-loaded monoolein gel. To prevent post-operative septicaemia, a systemic antibiotherapy was prescribed for 3 days following the operation. Clinical, biological and radiological follow-up was performed to assess the efficacy and the safety of the treatment. After a follow-up period ranging from 2 to 12 months, all 19 patients included in the study felt well. Eighteen patients recovered from chronic osteomyelitis without adverse events. The wound of one patient whose bone was exposed did not scar over after 10 months. However, it was no longer infected. In conclusion, gentamicin-loaded monoolein gel was efficacious in treating chronic osteomyelitis without side-effects.
PDF Fulltext XML References Citation

How to cite this article

Moustapha Ouedraogo, Christophe S. Da, Innocent S. Nacoulma, Hamado Kafando, Rasmane Semde, Issa T. Some, Rasmata Ouedraogo, Innocent P. Guissou, Brigitte Evrard, Viviane Henschel, Jacques Dubois and Karim Amighi, 2008. Preliminary Clinical Assessment of a Gentamicin-Loaded Monoolein Gel Intended to Treat Chronic Osteomyelitis. Trends in Medical Research, 3: 82-89.

URL: https://scialert.net/abstract/?doi=tmr.2008.82.89

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved