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Trends in Medical Research
  Year: 2007 | Volume: 2 | Issue: 1 | Page No.: 44-50
DOI: 10.3923/tmr.2007.44.50
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Cytotoxic Effect of Moringa oleifera Leaf Extracts on Human Multiple Myeloma Cell Lines

M.V.S. Parvathy and A. Umamaheshwari

In the present study different organic solvent extracts of dried leaves of country variety of Moringa oleifera (L) were evaluated for their cytotoxic potentiality on human Multiple myeloma cell lines. Different extracts of aqueous methanol, ethanol, ethyl acetate and chloroform from Moringa oleifera and Vinca rosea leaves were analysed for their cytotoxic effect by performing neutral red dye uptake assay to check for the viability of myeloma cells after treatment. Moringa leaf extracts exhibited pronounced cytotoxic effect (<15% viability at 0.2 mg mL-1) compared to Vinca extracts. Of the organic extracts, methanolic extracts of Moringa leaves showed least viability at highest dose (2%) and comparatively less viability at lowest dose (12%) with a sigmoidal dose responsive viability profile on cells representing an ID50 value of 0.32 μg mL-1. Overall, methanol was expected to be suitable organic solvent for the extraction of anti cancer i.e., antimyelomic compounds from Moringa oleifera.
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How to cite this article:

M.V.S. Parvathy and A. Umamaheshwari , 2007. Cytotoxic Effect of Moringa oleifera Leaf Extracts on Human Multiple Myeloma Cell Lines. Trends in Medical Research, 2: 44-50.

DOI: 10.3923/tmr.2007.44.50






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