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Trends in Medical Research
  Year: 2007 | Volume: 2 | Issue: 1 | Page No.: 12-20
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Experimental Models for Vascular Endothelial Dysfunction

Pitchai Balakumar, Seema Jindal, Dhvanit Indravadan Shah and Manjeet Singh

The endothelium is recognized as a physical barrier between blood and vascular wall. It regulates vascular tone, endothelial permeability and vascular growth. Dysfunction of endothelium has been characterized by partial or complete loss of balance between vasorelaxation and vasoconstriction, thrombosis and thrombolysis. Various experimental evidences have shown that endothelial dysfunction mainly occurs due to reduced nitric oxide production and increased oxidative stress. Vascular endothelial dysfunction is associated with pathogenesis of atherosclerosis, hypertension, diabetes mellitus, coronary artery diseases and stroke. In the present review, we have discussed various recently developed animal models for vascular endothelial dysfunction, which may open new vista to develop agents for improving vascular endothelial function.
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How to cite this article:

Pitchai Balakumar, Seema Jindal, Dhvanit Indravadan Shah and Manjeet Singh, 2007. Experimental Models for Vascular Endothelial Dysfunction. Trends in Medical Research, 2: 12-20.





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