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Trends in Medical Research
  Year: 2006 | Volume: 1 | Issue: 1 | Page No.: 75-85
DOI: 10.3923/tmr.2006.75.85
Susceptibility and Transmission Capacity of Subpopulations of Glossina pallidipes to Human Infective Trypanosoma brucei rhodesiense
S.O. Okoth, E.D. Kokwaro , J.M. Kiragu and G.A. Murila

Abstract:
The vectorial capacity of Glossina pallidipes from two allopatric populations of Kenya was evaluated. Tenerals flies from the two subpopulations were infected with T.b. rhodesiense in vivo, maintained in vitro and allowed to transmit the infection to susceptible mice 25 days post infection. Infection status of the flies was analyzed parasitologically and biochemically through microscopy and Polymerase Chain Reaction (PCR). Results showed that flies from Nguruman had lower survival rates and were less susceptible to trypanosome infection than those from Busia, although the differences were insignificant. There was no significant difference in infection rates of the proboscis, midgut and salivary gland between the subpopulations. Infection load of the dissected fly parts varied significantly among the Nguruman (F = 20.043, df = 2, p<0.001) and also among the Busia (F = 26.167; df = 2; p<0.001) subpopulations. Mean infection load and transmission success to mice between the two subpopulations were however not significantly different. An insignificant inverse correlation between means of PCV and parasitaemia was observed. However, trypanosome infection did not significantly vary PCV between infected and control mice. Implications of these results are discussed with respect to epidemiology of rhodesian sleeping sickness.
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How to cite this article:

S.O. Okoth, E.D. Kokwaro , J.M. Kiragu and G.A. Murila , 2006. Susceptibility and Transmission Capacity of Subpopulations of Glossina pallidipes to Human Infective Trypanosoma brucei rhodesiense. Trends in Medical Research, 1: 75-85.

DOI: 10.3923/tmr.2006.75.85

URL: https://scialert.net/abstract/?doi=tmr.2006.75.85

 
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