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Trends in Medical Research
  Year: 2006 | Volume: 1 | Issue: 1 | Page No.: 49-54
DOI: 10.3923/tmr.2006.49.54
Immunohistochemical Expression of Prostate-specific Membrane Antigen in Uveal Melanoma
Katyanne D. Godeiro, Emilia Antecka , Ana Carolina de A. Frota , Alexandre Nakao Odashiro , Shawn Maloney and Miguel N. Burnier

Abstract:
The purpose of this study was to characterize the expression of PSMA and evaluate its possible association with clinicopathological features in Uveal Melanoma (UM). Fifty-five UM specimens were subjected to immunohistochemistry with anti-PSMA monoclonal antibody. Prostatic hyperplasia was used as a positive control. The endothelial cells of the tumor-associated neovasculature and UM cells in all of the 55 UM cases demonstrated negative staining to PSMA. Since there is no expression of PSMA in UM, this protein does not represent a new target for antineovasculature-based therapy for UM patients. Therefore, the search for new treatments, especially those focusing on hematogenous metastatic spread, is necessary.
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How to cite this article:

Katyanne D. Godeiro, Emilia Antecka , Ana Carolina de A. Frota , Alexandre Nakao Odashiro , Shawn Maloney and Miguel N. Burnier , 2006. Immunohistochemical Expression of Prostate-specific Membrane Antigen in Uveal Melanoma. Trends in Medical Research, 1: 49-54.

DOI: 10.3923/tmr.2006.49.54

URL: https://scialert.net/abstract/?doi=tmr.2006.49.54

 
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