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Trends in Medical Research
  Year: 2006 | Volume: 1 | Issue: 2 | Page No.: 100-112
DOI: 10.3923/tmr.2006.100.112
Use of Ailanthus altissima and Ziziphus spina christi Extracts As Folk Medicine for Treatment of Some Hepatic Disorders In Schistosoma mansoni Infected Mice
N. Saba El-Rigal, S.A.Aly , M. Rizk and A. Said

Abstract:
The effect of Schistosoma mansoni infection on the activities of aspartate and alanine aminotransferases, acid phosphatase, 5’nucleotidase, glucose-6-phosphatase, lactate dehydrogenase, alkaline phosphatase and succinate dehydrogenase were estimated as measures of hepatic metabolic function. The effect of infection, on free radical production in the form of lipid peroxides and on the levels of certain antioxidants namely, catalase, glutathione, vitamins C and E was also studied. The efficiency of administration of the chloroform extract of Ailanthus altissima stem bark and the alcoholic extract of Ziziphus spina christi roots as antischistosomal and hepatoprotective agents in infected mice was evaluated. In addition, the efficiency of the tested extracts on reducing the worm burden and ova counts in the infected mice was evaluated. The obtained data revealed that infection with S.mansoni increased lipid peroxides and decreased all antioxidant levels. On the other hand, the activities of acid phosphatase and 5`nucleotidase were higher while those of glucose-6-phosphatase, lactate dehydrogenase, alkaline phosphatase and succinate dehydrogenase were lower with respect to control .However treatment with both A.altissima and Z.spina christi ameliorated the disturbed lipid peroxides, antioxidants and enzymes’ levels to nearly the control values, the choloroform extract of A.altissima showing a more pronounced improving effect against liver damage caused by parasitic infection. This study confirms the recent approach of many researchers for the use of plant extracts for treatment of liver diseases as alternatives to the classical chemotherapeutic drugs since the latter may cause hazardous side effects, besides the achieved tolerance to prolonged drug administration.
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How to cite this article:

N. Saba El-Rigal, S.A.Aly , M. Rizk and A. Said , 2006. Use of Ailanthus altissima and Ziziphus spina christi Extracts As Folk Medicine for Treatment of Some Hepatic Disorders In Schistosoma mansoni Infected Mice. Trends in Medical Research, 1: 100-112.

DOI: 10.3923/tmr.2006.100.112

URL: https://scialert.net/abstract/?doi=tmr.2006.100.112

 
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