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Trends in Bioinformatics
  Year: 2014 | Volume: 7 | Issue: 1 | Page No.: 7-12
DOI: 10.3923/tb.2014.7.12
 
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ECO-MP: E coli-Metabolic Pathway-development of Genome-scale Metabolic Pathway Database for Escherichia coli
Gopal Ramesh Kumar, Thankaswamy Kosalai Subazini and Ashok Selvaraj

Abstract:
Reconstruction of genome-scale metabolic pathway is an essential task to understand cellular processes in Escherichia coli K-12 species. ECO-MP, an E. coli metabolic pathway database is developed for the investigation of biosynthetic pathways of metabolic network. ECO-MP database is created by BLASTing protein sequences of E. coli against KEGG database and the sequences are categorized as known pathways, unknown and constructed pathways. Further, ECO-MP directs the gene or proteins to KEGG pathway in which they involved or otherwise it is linked to generate subnetworks using chemical reactions obtained from KEGG by network expansion method. Totally 2,560 known and 1,730 unknown proteins have been annotated to facilitate metabolic pathway reconstruction in E. coli. The subnetworks obtained from ECO-MP can be employed to fill the metabolic holes or to create an alternative pathway by means of network expansion method and it can be accessed at http://ecomp.bioinfo.au-kbc.org.in/.
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How to cite this article:

Gopal Ramesh Kumar, Thankaswamy Kosalai Subazini and Ashok Selvaraj, 2014. ECO-MP: E coli-Metabolic Pathway-development of Genome-scale Metabolic Pathway Database for Escherichia coli. Trends in Bioinformatics, 7: 7-12.

DOI: 10.3923/tb.2014.7.12

URL: https://scialert.net/abstract/?doi=tb.2014.7.12

 
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