This study determines conservation and functional divergence
of Methylenetetrahydrofolate reductase (MTHFR) focusing on sites which
bear single nucleotide polymorphisms (SNPs). We constructed its phylogeny
and calculated type 1 divergence to identify regions of MTHFR under selection.
We found that MTHFR is present throughout the three domains of life; Archaea,
Bacteria and Eukarya. MTHFR well conserved preserving its function. It
has been reported in earlier studies that polymorphisms in this gene are
potential modulators of therapeutic response to anticancer drugs. Hence,
SNPs in protein coding region were analyzed for the conservation and functional
constraints. We report in this study that SNPs of MTHFR gene occur at
sites under functional constraint i.e., these sites tend to be conserved.
It is possible that SNPs at such sites could be fixed and propagated in
a given population. PDFFulltextXMLReferencesCitation
How to cite this article
Muhummadh Khan and Kaiser Jamil, 2008. Study on the Conserved and the Polymorphic Sites of MTHFR Using Bioinformatics Approaches. Trends in Bioinformatics, 1: 7-17.