Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Trends in Bioinformatics
  Year: 2008 | Volume: 1 | Issue: 1 | Page No.: 7-17
DOI: 10.3923/tb.2008.7.17
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Study on the Conserved and the Polymorphic Sites of MTHFR Using Bioinformatics Approaches

Muhummadh Khan and Kaiser Jamil

Abstract:
This study determines conservation and functional divergence of Methylenetetrahydrofolate reductase (MTHFR) focusing on sites which bear single nucleotide polymorphisms (SNPs). We constructed its phylogeny and calculated type 1 divergence to identify regions of MTHFR under selection. We found that MTHFR is present throughout the three domains of life; Archaea, Bacteria and Eukarya. MTHFR well conserved preserving its function. It has been reported in earlier studies that polymorphisms in this gene are potential modulators of therapeutic response to anticancer drugs. Hence, SNPs in protein coding region were analyzed for the conservation and functional constraints. We report in this study that SNPs of MTHFR gene occur at sites under functional constraint i.e., these sites tend to be conserved. It is possible that SNPs at such sites could be fixed and propagated in a given population.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Structural and Functional Analysis of KIT Gene Encoding Receptor Tyrosine Kinase and its Interaction with Sunitinib and HDAC Inhibitors: An in silico Approach
  •    In silico Analysis of Deleterious SNPs of the FGFR2 Gene
How to cite this article:

Muhummadh Khan and Kaiser Jamil, 2008. Study on the Conserved and the Polymorphic Sites of MTHFR Using Bioinformatics Approaches. Trends in Bioinformatics, 1: 7-17.

DOI: 10.3923/tb.2008.7.17

URL: https://scialert.net/abstract/?doi=tb.2008.7.17

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 

Curve Bottom