The Protective Role of Royal Jelly Against Mutagenic Effect of Adriamycin and Gamma Radiation Separately and in Combination


	Trends in Applied Sciences Research
	Year: 2008 \| Volume: 3 \| Issue: 4 \| Page No.: 303-318 DOI: 10.3923/tasr.2008.303.318

The Protective Role of Royal Jelly Against Mutagenic Effect of Adriamycin and Gamma Radiation Separately and in Combination

Samia A. El-Fiky, Othman E. Othman, Esraa A. Balabel and Soheir A. Abd-Elbaset

Abstract: The present study investigated the protective role of royal jelly against mutagenic effect of adriamycin and/or cobalt gamma radiation in rats. The pretreatment of royal jelly for ten days before adriamycin treatment or/and gamma exposure showed a decrease in their mutagenic effect. Royal jelly administration decreased the different types of chromosomal aberrations induced by adriamycin without significant levels in 2nd, 4th, 7th and 14th days after adriamycin treatment, except the total structural aberrations with gaps in 7th day decreased significantly at p<0.05. Also the royal jelly pretreatment induced decreases of DNA fragmentation induced by adriamycin with a highly significant level (p<0.001) in 4th day after adriamycin treatment and this significant decrease continued for two weeks after adriamycin treatment. The result showed that there was no significant decrease in the number of aberrations in 2nd and 4th days after irradiation, while the total number of structural aberrations decreased significantly at p<0.01 in 7th day and at p<0.05 in 14th days after gamma exposure. Also, the royal jelly pretreatment induced a significant decrease of the DNA fragmentation in 2nd day after gamma exposure at a level p<0.01 and this significant increase reached to p<0.001 level in 4th, 7th and 14th after exposure. The statistical analysis showed that the royal jelly pretreatment decreased the numbers of all aberrations induced in combined treatment (adriamycin plus gamma radiation) group without any significant level, except the total number of structural aberrations in 2nd day where it decreased at p<0.05. The royal jelly pretreatment induced a decrease of DNA fragmentation without significant level in 2nd and 4th days after combined treatment and this decrease reached to the significant level at p<0.001 in 7th day and at p<0.05 in 14th day.

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How to cite this article:

Samia A. El-Fiky, Othman E. Othman, Esraa A. Balabel and Soheir A. Abd-Elbaset, 2008. The Protective Role of Royal Jelly Against Mutagenic Effect of Adriamycin and Gamma Radiation Separately and in Combination. Trends in Applied Sciences Research, 3: 303-318.

DOI: 10.3923/tasr.2008.303.318

URL: https://scialert.net/abstract/?doi=tasr.2008.303.318

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