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Singapore Journal of Scientific Research

Year: 2020 | Volume: 10 | Issue: 2 | Page No.: 175-181
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Authors

Sumaia A. Ali

Sumaia A. Ali

G.E. Mohammed

Ahmed A. Gameel

Keywords

Research Article

Nephroprotective Activity of Capparis decidua Aerial Parts Methanolic Extract in Wistar Albino Rats

Sumaia A. Ali Sumaia A. Ali's LiveDNA, G.E. Mohammed and Ahmed A. Gameel
Background and Objective: Traditionally, medicinal plants play a major role in the treatment of diseases. This study was aimed to investigate the nephroprotective effect of Capparis decidua aerial parts methanolic extract against gentamicin induced nephrotoxicity in Wistar albino rats. Materials and Methods: Twenty rats were divided into 4 groups of 5 rats each as follows, normal control, gentamicin induced nephrotoxicity injected intraperitoneal (IP) gentamicin 100 mg kg–1, C. decidua low dose (CDM200) given 200 mg kg–1 of methanolic extract orally and C. decidua high dose (CDM400) given 400 mg kg–1 of methanolic extract orally. Gentamicin was injected concurrently with the plant extract for 7 days. Urea and creatinine were determined to evaluate the nephroprotective action of C. decidua aerial parts methanolic extract against gentamicin induced nephrotoxicity. Blood was taken to evaluate complete blood picture. Histopathological examination of kidney sections was also performed. Results: The results indicated that the low and high doses of C. decidua aerial parts methanolic extract have potential nephroprotective action compared to gentamicin group (p<0.05) as evidenced by the significant decrease in the urea and creatinine levels compared to gentamicin group. Haematological parameters showed no significant differences between the test groups of rats. Rats that received gentamicin exhibited severe renal damage especially in the cortical tubules with presence of eosinophilic tubular cast in the medulla. These changes were less noticed in rats given low and high dosage of C. decidua methanolic extract. Conclusion: The result indicates the nephroprotective effect of C. decidua extract against toxic effects of gentamicin, which supports its folkloric use against renal disorders.
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How to cite this article

Sumaia A. Ali, G.E. Mohammed and Ahmed A. Gameel, 2020. Nephroprotective Activity of Capparis decidua Aerial Parts Methanolic Extract in Wistar Albino Rats. Singapore Journal of Scientific Research, 10: 175-181.

URL: https://scialert.net/abstract/?doi=sjsres.2020.175.181

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