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Singapore Journal of Scientific Research

Year: 2011 | Volume: 1 | Issue: 1 | Page No.: 13-22
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Authors

C.M. Sultanpur

S.V. Kumar

K. Deepa

Keywords

Review Article

Vaccines for Hypertension Disorder: Beneficial or Detrimental

C.M. Sultanpur, S.V. Kumar and K. Deepa
The prevalence of hypertension in the adult population was estimated to be 26.4% in 2000 and is projected to be 29.2% by 2025. Hypertension significantly increases the risk of developing disorders such as coronary artery disease, stroke, arrhythmia, heart failure, abnormal renal function and many other complications associated with structural damage to the cardiovascular system, hence the management of hypertension is very essential. Management of hypertension involves different approaches like life style modification and antihypertensive therapy. Life style modifications like weight reduction, discontinue smoking, limiting alcohol intake, increasing physical activity, reducing salt intake, increasing fruit vegetable intake, decreasing saturated and total fat intakes helps in managing hypertension. Antihypertensive therapy without co-morbidities involves administration of different classes of drugs like diuretics, angiotensin convertase enzyme, angiotensin receptor blockers, β blockers, calcium channel blockers, aldosterone antagonist and rennin inhibitors to achieve desired blood pressure intiating treatment with two drug combination may allow blood pressure targets to be reached earlier than monotherapy. This may lead to various adverse effects. Both the approaches requires patient adherence, which is a major problem in management of hypertension. To overcome the problem of patient compliance, research is going on the development of vaccines for hypertension, which produces antibodies against endogenous renin/angiotensin I and II. Vaccines for treatment of hypertension unlike other conventional, vaccine which is used for prevention of various diseases. Although, the concept is intriguing because excessive stimulation of immune system against endogenous substance may lead to autoimmune disorder like nephritis and also renin angiotensin system involved in the maintaining of homeostasis will be hampered. It’s better to use many excellent therapeutic options that are already available to inhibit the RAS, until efficient vaccine is developed.
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