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Science International
  Year: 2018 | Volume: 6 | Issue: 2 | Page No.: 71-79
DOI: 10.17311/sciintl.2018.71.79
Formulation, Development and Evaluation of a Novel Polymer-based Anti-Inflammatory Emulgel of Aceclofenac
Rashmi Godbole, Mihir Invally, Sarika Wairkar, Sukhwinder Bhullar and Ginpreet Kaur

Abstract:
Background and Objective: Aceclofenac is a non-steroidal anti-inflammatory drug used for pain relief and inflammation in certain joint disorders. Due to the hydrophobicity (BCS class II) of aceclofenac, it’s formulation into a topical gel is challenging. In this study, polymer-based emulgel formulation of aceclofenac with a microemulsion base was developed and assessed for its anti-inflammatory activity. Materials and Methods: Microemulsion of aceclofenac was formulated with various polymers and optimized. The optimized formulation was subjected to gelling, resulting in formulation of an emulgel. The resulting emulgel was optimized for desired pharmaceutical characteristics and later evaluated for anti-inflammatory effect in rats, comparing against the standard (most popular) marketed anti-inflammatory emulgel formulation. Results: The resultant microemulsion and emulgel both exhibited the desired drug release in-vitro and ex-vivo. The in vivo anti-inflammatory activity of topical aceclofenac emulgel on carrageenan induced paw edema model showed a time dependent response in reduction of inflammation showing the highest inhibition of 65.71%, which was significant compared with the placebo (p<0.005). Additionally, the activity of topical aceclofenac emulgel on croton oil induced ear edema model showed significant inhibition (p<0.05) of 47.86% after 4 h, compared to the placebo. Conclusion: The activity produced by the formulated emulgel was at par with the most marketed emulgel formulation. Thus, the microemulsion base improved the solubility of the drug and the emulgel formulation enhanced the delivery in a sustained manner. Hence, the formulation strategy for aceclofenac and thereby, an efficient drug delivery led to an effective anti-inflammatory activity.
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How to cite this article:

Rashmi Godbole, Mihir Invally, Sarika Wairkar, Sukhwinder Bhullar and Ginpreet Kaur, 2018. Formulation, Development and Evaluation of a Novel Polymer-based Anti-Inflammatory Emulgel of Aceclofenac. Science International, 6: 71-79.

DOI: 10.17311/sciintl.2018.71.79

URL: https://scialert.net/abstract/?doi=sciintl.2018.71.79

 
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