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Pharmacokinetics of Cefpirome Following Intravenous and Intramuscular Administration
in Cow Calves |
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R.B. Patel,
S.K. Bhavsar,
P.F. Solanki,
J.H. Patel,
R.D. Varia,
D. Modi Falguni and M.D. Patel |
Abstract:
Background: Cefpirome is a broad-spectrum semi synthetic β-lactamase
resistant fourth generation cephalosporin. Looking to potential for clinical
use, pharmacokinetics of cefpirome following intravenous and intramuscular administration
(10 mg kg-1) in cow calves was determined. Methods: Cefpirome
concentration in plasma samples was determined by reverse-phase high performance
liquid chromatography with mobile phase. The mobile phase was a mixture of 0.2
M sodium acetate (3.5%), acetronitrile (17.5%) and HPLC water (79%) with a pH
of 5.1. Mobile phase was filtered by 0.45 μ filters and pumped into column
at a flow rate of 1.0 mL min-1 at ambient temperature. The effluent
was monitored at 258 nm wavelength. Results: Following intravenous administration
of the cefpirome in goats, volume of distribution at steady-state (Vdss),
elimination half-life (t1/2β) and total body clearance (ClB)
were reported 0.33±0.01 L kg-1, 2.41±0.23 h and 2.36±0.18
mL min-1 kg-1, respectively. Following intramuscular administration
of the drug, peak plasma concentration (Cmax), elimination half-life
(t½β), apparent volume of distribution (Vdarea),
total body clearance (ClB), bioavailability (F) were 13.27±0.19
μg mL-1, 3.61±0.12 h, 0.81±0.007 L kg-1,
2.83±0.08 mL min-1 kg-1 and 61±1%, respectively.
Conclusion: Pharmacokinetic – pharmacodynamics integration indicates
cefpirome can be useful in cow calves at dose rate of 10 mg kg-1
and repeated at interval of 12 h by intramuscular route.
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How to cite this article:
R.B. Patel, S.K. Bhavsar, P.F. Solanki, J.H. Patel, R.D. Varia, D. Modi Falguni and M.D. Patel, 2013. Pharmacokinetics of Cefpirome Following Intravenous and Intramuscular Administration
in Cow Calves. Science International, 1: 371-374.
URL: https://scialert.net/abstract/?doi=sciintl.2013.371.374
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