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Research Journal of Veterinary Sciences
  Year: 2018 | Volume: 11 | Issue: 1 | Page No.: 1-10
DOI: 10.3923/rjvs.2018.1.10
Assessment of Anticoccidial and Antioxidant Efficacy of Methanolic Extract of Pentaclethra macrophylla on Rabbits
Yamssi Cedric , Vincent Khan Payne , Noumedem Anangmo Christelle Nadia, Norbert Kodjio, Etung Kollins, Leonelle Megwi, Jules-Roger Kuiate and Mpoame Mbida

Abstract:
Background and Objective: Coccidiosis caused by protozoans of the Eimeria genus is a serious problem for the health of rabbits (Oryctolagus cuniculus) and their production. This study was therefore carried out in order to scientifically validate the use of Pentaclethra macrophylla in fighting against Coccidiosis. Materials and Methods: A total of 48 domestic rabbits (60 days old and about 1.5-2 kg b.wt.) and free from coccidia infection were used. All groups except group 6 were infected with 1000 sporulated Eimeria intestinalis oocysts. Faecal samples were collected and examined starting on day 1 post-inoculation until Day 9 post-inoculation, during which oocysts appeared in faeces. For quantitative analysis or determination of the number of oocysts per gram (OPG) of faeces, the Mc Master technique was used. Serum was used for determination of biochemical parameters related to oxidative stress such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), malondialdehyde (MDA), nitric oxide (NO) and glutathione using standardized diagnostic kits and a spectrophotometer. Results: The highest oocyst count reduction rate was 95% in the group which received the standard anti-coccidial drug. Among the groups that received the plant extract, the highest oocyst reduction rate was 69.41% at a dose of 500 mg kg–1 and reduced in a dose-dependent manner from 58.92% (250 mg kg–1) and then 55.01% (125 mg kg–1). The result showed a significant decrease in tissues and serum catalase and peroxidase and a significant increase in NO, MDA and GLU levels in negative control animals. Treatment resulted in a significant normalization of the levels of the above markers when compared with the neutral control group. Conclusion: Our findings, therefore scientifically validate the use of P. macrophylla in fighting against Coccidiosis.
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How to cite this article:

Yamssi Cedric, Vincent Khan Payne, Noumedem Anangmo Christelle Nadia, Norbert Kodjio, Etung Kollins, Leonelle Megwi, Jules-Roger Kuiate and Mpoame Mbida, 2018. Assessment of Anticoccidial and Antioxidant Efficacy of Methanolic Extract of Pentaclethra macrophylla on Rabbits. Research Journal of Veterinary Sciences, 11: 1-10.

DOI: 10.3923/rjvs.2018.1.10

URL: https://scialert.net/abstract/?doi=rjvs.2018.1.10

 
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