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Research Journal of Veterinary Sciences

Year: 2015 | Volume: 8 | Issue: 1 | Page No.: 8-14
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Authors

R.I.O. Nwoha

B.M. Anene

Keywords

Research Article

Alteration in Humoural Immune Response to Canine Dystemper Vaccination in Dogs Experimentally Infected with Single Trypanosma brucei and Trypanosoma congolense Infections

R.I.O. Nwoha and B.M. Anene
The effect of single Trypanosma brucei and Trypanosoma congolense infections and treatment on vaccination was determined. Twelve dogs were grouped into three, each containing four members. Group I (GPI) was the uninfected control, GPII-infected with T. congolense and GPIII-infected with T. brucei. The prepatent period were 5.00±1.30 in T. brucei brucei and 14.00±1.40 in T. congolense infected groups. The dogs were first inoculated with Canine Distemper (CD) vaccine before infection with T. congolense and T. brucei 6 weeks later. At one week post vaccination, the antibody titre in all the vaccinated groups (GPI, GPII and GPIII) significantly increased (p<0.05) and reached to peak levels at 3 weeks post vaccination. Subsequently, there were gradual significant decrease (p<0.05) in GPII and GPIII compared to the control (GPI). There was no difference between the decrease in antibody recorded in both GPII and GPIII. Treatment with diminazene aceturate did not significantly (p<0.05) improve antibody response in the dogs. A secondary post primary vaccination was administered at 12 weeks vaccination which significantly increased (p<0.05) the antibody titer with a peak 3 weeks post-secondary vaccination.
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How to cite this article

R.I.O. Nwoha and B.M. Anene, 2015. Alteration in Humoural Immune Response to Canine Dystemper Vaccination in Dogs Experimentally Infected with Single Trypanosma brucei and Trypanosoma congolense Infections. Research Journal of Veterinary Sciences, 8: 8-14.

URL: https://scialert.net/abstract/?doi=rjvs.2015.8.14

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