Protective Effects of Garlic Extract and Vitamin C Against Cypermethrin Reproductive Toxicity in Male Rats


	Research Journal of Veterinary Sciences
	Year: 2008 \| Volume: 1 \| Issue: 1 \| Page No.: 1-15 DOI: 10.3923/rjvs.2008.1.15

Protective Effects of Garlic Extract and Vitamin C Against Cypermethrin Reproductive Toxicity in Male Rats

M.E. Assayed, H.A. Salem and A.A. Khalaf

Abstract: The toxicological properties of the synthetic pyrethroid insecticide Cypermethrin (CYP) on testes and the fertility parameters of male white rats as well as possible protective roles of two natural elements: garlic extract (GRE, 500 mg kg^-1) and vitamin C (VTC, 20 mg kg^-1) against the insecticide toxicity were assessed. CYP was administered orally either alone, concomitantly with each individual stuff, or with their combination (GRE or/and VTC); as repeated daily administration for 5 consecutive days. Present data cleared that CYP adversely affected male reproductive function as revealed by the significant abnormal spermatozoal parameters and histopathological alterations in testicular tissue along the whole experimental period. On the other hand, this investigation fundamentally cleared the protective and/or ameliorative role played by GRE and VTC; either each alone or in combination against the toxicological aspects of Cypermethrin; providing that garlic extract was often more efficient in its protective action against the insecticide toxicity than vitamin C and that the combination of both natural elements was in most cases more advantageous than when each one was administered alone.

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How to cite this article:

M.E. Assayed, H.A. Salem and A.A. Khalaf, 2008. Protective Effects of Garlic Extract and Vitamin C Against Cypermethrin Reproductive Toxicity in Male Rats. Research Journal of Veterinary Sciences, 1: 1-15.

DOI: 10.3923/rjvs.2008.1.15

URL: https://scialert.net/abstract/?doi=rjvs.2008.1.15

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