Science Alert
 
Blue
   
Curve Top
Research Journal of Phytochemistry
  Year: 2021 | Volume: 15 | Issue: 2 | Page No.: 51-57
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Activity of Terminalia chebula and Erythrina variegata Extracts Against Pathogen Causing Respiratory Tract Infection

Chandrika Das, Dil Umme Salma Chowdhury, Abdul Mannan and Nazneen Naher Islam

Abstract:
Background and Objective: Respiratory Tract Infections (RTIs) are one of the leading causes of morbidity and mortality worldwide. As the bacterial resistance towards commercially available antibiotics indicated for microorganisms associated with RTIs is increasing, the need of finding an appropriate alternative antimicrobial agent is also on the rise. Therefore, the present study was executed to explore the antibacterial activity of the acetone extracts of two medicinal plants, Terminalia chebula and Erythrina variegata against antibiotic-resistant Staphylococcus aureus. Materials and Methods: For this study, the presence of S. aureus in the human sputum samples was ensured by growing culture on Mannitol Salt Agar (MSA) and performing a battery of biochemical tests. Culture sensitivity tests were done to determine the antibiotic susceptibility pattern of S. aureus. MAR index of S. aureus isolates was also calculated to determine if they are resistant to more than one antibiotic. The antimicrobial activity of the plant extracts was determined using a disc diffusion assay. Results: The isolates were found highly resistant to Erythromycin (68.97%) and least resistant towards Chloramphenicol (13.79%). The high MAR index (>0.2) has signified the exposure of S. aureus to multiple antibiotics. Acetone extracts collected from the two plants showed the highest activity at 5 mg mL–1 among the three different concentrations used (1.25, 2.5 and 5 mg mL–1) in the study. It was also observed that the extracts from T. chebula exhibited better antibacterial activity than that of E. variegata against S. aureus isolates. Conclusion: T. chebula and E. variegata extracts could be further investigated as potential antibacterial agents to treat respiratory tract infection.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Chandrika Das, Dil Umme Salma Chowdhury, Abdul Mannan and Nazneen Naher Islam, 2021. Activity of Terminalia chebula and Erythrina variegata Extracts Against Pathogen Causing Respiratory Tract Infection. Research Journal of Phytochemistry, 15: 51-57.

URL: https://scialert.net/abstract/?doi=rjphyto.2021.51.57

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
Curve Bottom