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Research Journal of Phytochemistry
  Year: 2018 | Volume: 12 | Issue: 1 | Page No.: 43-51
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Toxicological Evaluation of Psychotria microphylla Crude Extract on Rats

O.U. Orji, C.J. Chukwu , U.A. Ibiam and U.C. Okorie

Background and Objective: Psychotria microphylla Elmer is used in South Eastern Nigeria in fish harvesting. Though apparently believed non-toxic to humans, there are no scientific reports available regarding the toxicity of this plant on rats. This study was designed to evaluate the safety of P. microphylla leaves extract in wistar albino rats. Materials and Methods: The method of Lorke was used to determine the acute toxicity using 14 rats. In the sub-acute phase, twenty five albino rats were randomly divided into five groups (A-E) of 5 rats each. Group A served as control and received 0.5 mL normal saline, Groups B, C, D and E received 300, 500, 1000 and 2000 mg kg–1 b.wt., respectively for 21 days orally. The results obtained were analyzed using SPSS for windows version 20. Results: The results showed that the crude leave extract of Psychotria microphylla did not cause any mortality at all doses up to 5000 mg kg–1 b.wt. The extract also did not produce any marked (p>0.05) effect on the haematological indices analyzed. However, oral administration of P. microphylla leave extract did cause significant reduction at (p<0.05) in triacylglycerols, total cholesterol and glucose levels in the rats in dose dependent manner. The extract did not cause significant impact on hepatic and renal functions at lower doses. Conclusion: In conclusion, this extract did not elicit significant effect on the immune, hepatic and renal systems and could be useful in the management of lipid related diseases due to its hypolipidemic activities.
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How to cite this article:

O.U. Orji, C.J. Chukwu, U.A. Ibiam and U.C. Okorie, 2018. Toxicological Evaluation of Psychotria microphylla Crude Extract on Rats. Research Journal of Phytochemistry, 12: 43-51.




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