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Research Journal of Phytochemistry
  Year: 2018 | Volume: 12 | Issue: 1 | Page No.: 35-42
DOI: 10.3923/rjphyto.2018.35.42
Assessment of Anticancer, Anti-inflammatory and Antioxidant Properties of Isoflavones Present in Soybean
Shashank Ashokrao Tidke , Arpitha Mahajankatti, Yashas Devasurmutt, Ramakrishna Devappa, Kiran Sunderarajarao Vasist, Georgina Kosturkova and Ravishankar Gokare Aswathanarayana

Abstract:
Background and Objective: Soybean (Glycine max) is highly valued source of protein and vegetable oil with several health benefits such as low plasma cholesterol and preventing cancer. Cancer accounts for 10% of total death worldwide, which requires superior therapeutic strategies. Isoflavones are a class of plant-derived compounds, which is mainly produced by Fabaceae family that has been reported to exhibit anticarcinogenic, antioxidant and anti-inflammatory properties. The objectives was to investigate the binding potential of selected isoflavones against the probable drug targets of various types of cancer and provide an insight on the anti-inflammatory and antioxidant properties by computer assisted virtual screening method. Materials and Methods: Twenty two receptors were analyzed for anticancer, two for anti-inflammatory and three for antioxidant studies. The binding competences of isoflavones (Daidzein, Genistein and Glycitein) towards selected targets were studied by molecular docking. Result: Affinity of isoflavones as an anticancer agent with respect specific target viz EGF, NFKBIA, PIK3CA, PTEN and RB1 was evident. The binding energies of docked complex were found to be -103.59, -90.675, -100.73, -105.68 and -109.2 kcal mol–1, respectively. COX-1 receptor showed best binding interaction with binding energies -110.38, -116.48 and -104.35 kcal mol–1, respectively, Catalase receptor showed high-energy interaction with binding energies -100.66, -94.02 and -97.53 kcal mol–1, respectively. Hence COX-1 and catalase were formed to be efficient target for anti-inflammatory and antioxidant site, respectively. Conclusion: Present study revealed that isoflavones has superior interacting properties towards these cancer targets than their normal ligands or predictable antitumor agents and strong approach to anti-inflammatory and antioxidant activity.
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How to cite this article:

Shashank Ashokrao Tidke, Arpitha Mahajankatti, Yashas Devasurmutt, Ramakrishna Devappa, Kiran Sunderarajarao Vasist, Georgina Kosturkova and Ravishankar Gokare Aswathanarayana, 2018. Assessment of Anticancer, Anti-inflammatory and Antioxidant Properties of Isoflavones Present in Soybean. Research Journal of Phytochemistry, 12: 35-42.

DOI: 10.3923/rjphyto.2018.35.42

URL: https://scialert.net/abstract/?doi=rjphyto.2018.35.42

 
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