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Evaluation of Anti-Alzheimer Activity of Ampelopsis brevipedunculata and the Isolated Compounds |
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Khaled Rashed,
Ataa Said,
Chistiane Feitosa and Ana Carolina Cardoso Sucupira |
Abstract:
Medicinal plants are main target for discovery of new drugs for treatment of many diseases. This study evaluated anti-Alzheimer activity of methanol (80%) extract of Ampelopsis brevipedunculata aerial parts and the isolated compounds. Anti-Alzhemier activity for (1) 5, 7-dihydroxy flavanone (pinocembrin), (2) 5, 7-dihydroxy-3, 6, 4'-trimethoxy flavone (santin), (3) Acacetin (4'-methoxy apigenin), (4) Acacetin 7-O-α-rhamnoside, (5) Acacetin 7-O-β-glucoside, (6) Luteolin 7-O-α-rhamnoside, (7) Apigenin 7-O-β-glucoside, (8) Apigenin 7-O-β-glucuronide and A. brevipedunculata extract was detected according to Ellman's method. The results showed that A. brevipedunculata extract and the compounds 2, 6 and 8 were active as anti-Alzheimer agents. The extract showed IC50 = 0.62 μg mL-1 while IC50 = 0.44 μg mL-1, IC50 = 0.32 μg mL-1 and IC50 = 0.56 μg mL-1 for the compounds 2, 6 and 8, respectively, neostigmine (IC50 = 1.87 μg mL-1) was used as positive control. These results showed that A. brevipedunculata extract and the isolated compounds can be promising agents for treatment of Alzheimer's disease in the future.
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How to cite this article:
Khaled Rashed, Ataa Said, Chistiane Feitosa and Ana Carolina Cardoso Sucupira, 2015. Evaluation of Anti-Alzheimer Activity of Ampelopsis brevipedunculata and the Isolated Compounds. Research Journal of Phytochemistry, 9: 16-24.
URL: https://scialert.net/abstract/?doi=rjphyto.2015.16.24
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