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Research Journal of Phytochemistry
  Year: 2014 | Volume: 8 | Issue: 3 | Page No.: 127-132
 
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Anti-inflammatory Constituent from the Root of Rhaphiostylis beninensis(Icacinaceae)

J.O. Ofeimun, B.A. Ayinde, I. Igbe, M. Aderogba, A. Adhikari, H. Amjad and M.C. Iqbal

Abstract:
Rhaphiostylis beninensis is a medicinal plant and a seasoning agent. Some biological and pharmacological reports have been made on the plant root bark extracts. There is a dearth of information on the phytochemical constituents of the plant, this study focused on the isolation and characterization of its components. After defatting with petroleum ether, the plant material was extracted with methanol. The extract obtained was partitioned into chloroform and aqueous phases followed by VLC of the chloroform fraction using hexane with increasing concentration of chloroform and ethyl acetate. Repeated column chromatography of combined fractions (3-5) and further purification on Sephadex LH-20 and preparative thin layer chromatography afforded compound 1. It was characterized using spectroscopic techniques (NMR and MS) and identified to be N, N-di (4-methoxybenzyl) thiourea. In the inhibition of rat-paw edema induced by carragenan, the compound (20 mg kg-1) slightly produced higher inhibitory effect than indomethacine (10 mg kg-1). It’s occurrence in this plant and its anti inflammatory potential are reported for the first time.
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How to cite this article:

J.O. Ofeimun, B.A. Ayinde, I. Igbe, M. Aderogba, A. Adhikari, H. Amjad and M.C. Iqbal, 2014. Anti-inflammatory Constituent from the Root of Rhaphiostylis beninensis(Icacinaceae). Research Journal of Phytochemistry, 8: 127-132.

URL: https://scialert.net/abstract/?doi=rjphyto.2014.127.132

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