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Research Journal of Phytochemistry
  Year: 2012 | Volume: 6 | Issue: 4 | Page No.: 120-126
 
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Total Phenolic Content, Antioxidant Activity and in vitro Inhibitory Potential against Key Enzymes Relevant for Hyperglycemia of Bridelia ferruginea Extracts

Batomayena Bakoma, Benedicte Berke, Kwashie Eklu-Gadegbeku, Aboudoulatif Diallo, Amegnona Agbonon, Kodjo Aklikokou, Messanvi Gbeassor and Nicholas Moore

Abstract:
Herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. Bridelia ferruginea is one of the traditional remedies used for diabetes in Togo. In this study, we determined phenolic profiles, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia of hydroethanolic extract, acetonic fraction and ethyl acetate fraction. The inhibitory activity against α-amylase, α-glucosidase was carried out. Antioxidant activity was evaluated using AAPH radical scavenging assay. Ethyl acetate fraction possessing high content of phenolics and antioxidant activity showed also high activities on key enzyme (α-glucosidase IC50 = 0.19 mg mL-1, α-amylase (IC50 = 0.24 mg mL-1) than acetonic fraction and hydroethanolic extract which have IC50>0.25 mg mL-1. These results suggest that Bridelia ferruginea has effective enzyme inhibitory activity useful for the management of postprandial hyperglycemia. Our study provided a strong rationale for further clinical studies and showed that anti-hyperglycemia compound of Bridelia ferruginea may be concentrated in the ethyl acetate fraction.
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How to cite this article:

Batomayena Bakoma, Benedicte Berke, Kwashie Eklu-Gadegbeku, Aboudoulatif Diallo, Amegnona Agbonon, Kodjo Aklikokou, Messanvi Gbeassor and Nicholas Moore, 2012. Total Phenolic Content, Antioxidant Activity and in vitro Inhibitory Potential against Key Enzymes Relevant for Hyperglycemia of Bridelia ferruginea Extracts. Research Journal of Phytochemistry, 6: 120-126.

URL: https://scialert.net/abstract/?doi=rjphyto.2012.120.126

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