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Research Journal of Phytochemistry
  Year: 2011 | Volume: 5 | Issue: 2 | Page No.: 70-79
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Isolation of Anti Ulcer Cucurbitane Type Triterpenoid from the Seeds of Cucurbita pepo

N.S. Gill and M. Bali

The present study has reported the isolation, characterization, antioxidant and antiulcer activity of a new triterpenoid extracted from Cucurbita pepo seeds. The seed extract was subjected to column chromatography for the isolation of constituents. The isolated compound was characterized by Infra red, 1Hydrogen Nuclear Magnetic Resonance, 13Carbon Nuclear Magnetic Resonance which allow the identification of isotopic hydrogen and carbon atoms in a molecule, respectively. The isolated compound was a tetracyclic triterpenoid which possesses basic cucurbitacin skeleton characterized as 19-(10→9β)-abeo-10α-lanost-5-ene. The isolated compound showed maximum antioxidant activity i.e. 72.8±0.15% by 1, 1 diphenyl -2- picryl hydrazyl method at 300 μg mL-1 as compared to ascorbic acid. Further, it was evaluated for anti ulcerogenic activity, extracted triterpenoid showed optimum percentage inhibition i.e., 55.7, 67.1 and 59.1% by Pyloric Ligation, Water Immersion Stress and NSAID (Indomethacin) induced ulcer method at 300 μg mL-1 dose in rats. It can be inferred from the above study that the extracted tetracyclic triterpenoid have potent anti-ulcer activity due to its antioxidant potential and can be used as natural antiulcerogenic agent.
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  •    Evaluation of Antioxidant, Antiinflammatory and Antiulcer Potential of Momordica charantia Methanolic Seed Extract
  •    Evaluation of Ethanolic Seed Extract of Lagenaria siceraria for Their Therapeutic Potential
  •    Antioxidant and Prebiotic Potential of Some Cucurbits
  •    Nutritional and Sensory Quality of Cookies Supplemented with Defatted Pumpkin (Cucurbita pepo) Seed Flour
  •    In vitro Antioxidant Property of Some Indian Medicinal Plants
  •    Pharmacology and Phytochemistry of Pakistani Herbs and Herbal Drugs Used for Treatment of Diabetes
  •    Phytopharmacological Profile of Lagenaria siceraria: A Review
  •    Hepatoprotective Activity of Coccinia grandis Leaves Against Carbon Tetrachloride Induced Hepatic Injury in Rats
How to cite this article:

N.S. Gill and M. Bali, 2011. Isolation of Anti Ulcer Cucurbitane Type Triterpenoid from the Seeds of Cucurbita pepo. Research Journal of Phytochemistry, 5: 70-79.




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