Dysophylla myosuroides and Talinum cuneifolium are medicinal plants used for different diseases. The present work was aimed to screen these medicinal plants for phytochemical studies. The dry powder of plant parts were extracted with different solvents by using soxhlet apparatus. Leaves of Dysophylla myosuroides revealed the presence of flavonoids, phenols, glycosides, terpenoids, saponins, steroids and volatile oils and absence of alkaloids, lignin, tannins, quinones and fixed oils. Whereas, tubers and leaves of Talinum cuneifolium showed that the presence of flavonoids, glycosides, saponins and steroids and absence of alkaloids, phenols, lignin, tannins, terpenoids, quinones, fixed oils and volatile oils. Both the plants showed variation in the synthesis of secondary metabolites. Dysophylla myosuroides accumulates more number of secondary metabolites than that of Talinum cuneifolium. Methanol and hexane are found to be efficient solvents for Talinum cuneifolium and Dysophylla myosuroides, respectively. Tuber of Talinum cuneifolium synthesized more number of secondary metabolites than that of leaves, methanol the most efficient solvent to extract the phytochemicals from tuber and leaves of Talinum.