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Research Journal of Phytochemistry
  Year: 2011 | Volume: 5 | Issue: 3 | Page No.: 156-162
DOI: 10.3923/rjphyto.2011.156.162
Isolating and Screening Mangrove Microalgae for Anticancer Activity
L.T.P. Hoa, D.N. Quang, N.T.H. Ha and N.H. Tri

Abstract:
Microalgae are valuable source of many unique biologically active compounds including anticancer compounds. In this study, sixteen microalgal strains were successfully isolated from mangrove in Xuanthuy National Park, Namdinh, Vietnam. Relative identification for each train was obtained based on morphological properties and 18 S rDNA sequence analysis. Culture extracts of these strains were tested against KB (human epidermal carcinoma) cell line. Ankistrodesmus gracilis VACC-010 and Amphiprora alata VACC-007 showed strongest inhibition with their IC50 values of 26.50 and 29.82 μg mL-1, respectively. Ankistrodesmus gracilis VACC-010 was also significantly effective against HepG2 (hepatocellular carcinoma) cell line (IC50 values of 9.64 μg mL-1), suggesting a potential source of anticancer compounds. To our knowledge, this is the first report on the anticancer activity of this strain as well as the first screening of mangrove microalgae for biologically active compounds, providing a new lead to the characterization and development of promising anticancer drugs.
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How to cite this article:

L.T.P. Hoa, D.N. Quang, N.T.H. Ha and N.H. Tri, 2011. Isolating and Screening Mangrove Microalgae for Anticancer Activity. Research Journal of Phytochemistry, 5: 156-162.

DOI: 10.3923/rjphyto.2011.156.162

URL: https://scialert.net/abstract/?doi=rjphyto.2011.156.162

 
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