Subscribe Now Subscribe Today
Science Alert
Curve Top
Research Journal of Phytochemistry
  Year: 2011 | Volume: 5 | Issue: 3 | Page No.: 136-145
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Pycnanolide A and B: New Lignan Lactones from the Leaves of Pycnanthus angolensis (Myristicaceae)

P.A. Onocha and M.S. Ali

Pycnanthus angolensis has wide application in ethnomedicine and is thus a rich source of medicinally important natural products. The leaf methanolic extract of Pycnanthus angolensis was investigated with the aim of isolating and elucidating the structures of the phytochemical constituents of the plant extract. Isolation and purification of pure compounds was achieved using standard chromatographic techniques. Spectroscopic techniques were used in structural elucidation of new compounds. Two new lignan-lactones, Pycnanolide A and B, were obtained along with four other compounds. The four compounds were identified as β-sitosterol, stigmasterol, phytol and hexadecanoic acid, of which the latter two are encountered for the first time in the plant. Pycnanolide A and B were characterized as (8α, 7'α, 8'β)-3, 4: 3', 4' bis (methylenedioxy) lignan-9, 7'-olide and (8β, 7'β, 8'β)-3, 4: 3',4' bis (methylenedioxy) lignan-9, 7'-olide, respectively. This study helped to characterize the structure of two new lignans-lactones which could form the basis of chemical synthesis and may provide the nucleus for development of new drugs.
PDF Fulltext XML References Citation Report Citation
  •    Preliminary Investigation into the Chemical Properties of Peperomia pellucida L.
  •    Phytochemical Analysis of Acanthus ilicifolius and Avicennia officinalis By GC-MS
  •    Chemical Composition, Cytotoxicity and Antioxidant Activity of Essential Oils of Acalypha hispida Flowers
  •    Cytotoxicity and Free Radical Scavenging Activities of Hexane Fractions of Nigeria Specie of African Pear (Dacryodes edulis)
  •    Potential Phytochemical from Caesalpinia crista Linn.
How to cite this article:

P.A. Onocha and M.S. Ali, 2011. Pycnanolide A and B: New Lignan Lactones from the Leaves of Pycnanthus angolensis (Myristicaceae). Research Journal of Phytochemistry, 5: 136-145.




Curve Bottom