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Research Journal of Phytochemistry
  Year: 2010 | Volume: 4 | Issue: 1 | Page No.: 1-12
DOI: 10.3923/rjphyto.2010.1.12
Feeding Wheat Germ Meal and Wheat Germ Oil Reduced Azoxymethane-induced Colon Tumors in Fisher 344 Male Rats
R. Field, M. Verghese, V. Panala, L. Shackelford, J. Boateng and L.T. Walker

Abstract:
Wheat germ contains phytates, phenolics, ligans, phytosterols, vitamin E and B, which have been proposed to offer protection against chronic diseases such as colon cancer. Present aim was to determine the effects of feeding wheat germ (WGM) at 5 and 10% and Wheat Germ Oil (WGO) at 7 and 14% on Azoxymethane-induced colon carcinogenesis Fisher 344 male rats. Hepatic Glutathions-S-Transferase (GST), a crucial Phase II detoxification enzyme was determined. Following a 1 week period of acclimatization, rats were assigned to 6 groups and fed AIN-93G with 7% SBO and 14% SBO as controls. The rats fed WGO received AIN-93G with 7 and 14% WGO and the rats fed WGM received 5% WGM and 10% WGM. Rats were killed at 46 weeks by CO2 asphyxiation. Reductions in tumor incidence in rats fed WGM (5%), WGM (10%), WGO (7%) and WGO (14%) compared to the control were 42, 58, 33.4 and 16.7, respectively. There were no significant (p<0.05) differences in hepatic GST activity (μmol mg-1) among rats fed (5% (29) and 10% (33)) WGM, however hepatic GST activity in the rats fed WGM was significantly (p<0.05) higher than the control. Wheat germ products did offer protection against development of AOM- induced colon tumors. Although dietary fat is known to be a tumor promoter, type of fat may be as important as the amount consumed.
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How to cite this article:

R. Field, M. Verghese, V. Panala, L. Shackelford, J. Boateng and L.T. Walker, 2010. Feeding Wheat Germ Meal and Wheat Germ Oil Reduced Azoxymethane-induced Colon Tumors in Fisher 344 Male Rats. Research Journal of Phytochemistry, 4: 1-12.

DOI: 10.3923/rjphyto.2010.1.12

URL: https://scialert.net/abstract/?doi=rjphyto.2010.1.12

 
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