Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Research Journal of Phytochemistry
  Year: 2009 | Volume: 3 | Issue: 2 | Page No.: 25-34
DOI: 10.3923/rjphyto.2009.25.34
Suppression of Colon Cancer Development in an Azoxymethane-Fisher 344 Rat Model by Cranberry
R. Sunkara, M. Verghese, L.T. Walker and L. Shackelford

Abstract:
The present study investigated the effect of cranberries on development of colon tumors induced by azoxymethane in Fisher 344 male rats. Fifty five rats were divided into five groups and fed with control (AIN 93) or treatment diets: cranberry meal (5, 10%) cranberry juice (2.5, 5%). Two AOM (16 mg kg-1 b.wt.) injections were given weekly for 2 weeks for induction of colon tumors. At 45 weeks of age, all rats were killed and colons were evaluated for tumor incidence, size of tumor and tumor multiplicity. Selected hepatic phase 1 (CYP2E1), phase 11 (GST) and antioxidative enzyme (catalase and SOD) activities were determined. Tumor size and tumors/tumor bearing rat were higher (p≤0.05) in the control group. Number of tumors was lower in cranberry fed rats compared to control. Administration of cranberry to rats increased (p<0.05) hepatic enzyme activities by 1.2-3.7 fold compared to control fed rats. These results indicate that feeding cranberry (meal and juice) inhibited colon tumors induced by AOM and enhanced the activity of hepatic enzymes.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Chemopreventive Potential of Cranberries on Azoxymethane Induced Aberrant Crypt Foci in Fisher 344 Male Rats
How to cite this article:

R. Sunkara, M. Verghese, L.T. Walker and L. Shackelford, 2009. Suppression of Colon Cancer Development in an Azoxymethane-Fisher 344 Rat Model by Cranberry. Research Journal of Phytochemistry, 3: 25-34.

DOI: 10.3923/rjphyto.2009.25.34

URL: https://scialert.net/abstract/?doi=rjphyto.2009.25.34

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 

       

       

Curve Bottom