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Research Journal of Phytochemistry
  Year: 2008 | Volume: 2 | Issue: 2 | Page No.: 69-76
DOI: 10.3923/rjphyto.2008.69.76
 
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Determination of Antioxidant Contents in Red Sorrel and its nticarcinogenic Potential in Azoxymethane-Induced Colonic Aberrant Crypt Foci

M. Verghese, M. S.C. Fullerton, L. T. Walker, L. A. Shackelford, E. Cebert, J. Boateng, S. Ogutu, J. Khatiwada, M. Guyton, J. Jones and C. B. Chawan

Abstract:
The aim of the study was to determine the antioxidant properties in sorrel and to evaluate the effect of feeding red sorrel on azoxymethane-induced Aberrant Crypt Foci (ACF) in Fisher 344 rats. Total phenolics and flavonoids were spectrophotometrically determined using gallic acid and catechin as standards and antioxidant capacity was determined using 2, 2`-azinobis [(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)] radical scavenging assay, with vitamin C (ascorbic acid) as standard. Twenty-four Fisher 344 rats were divided into 3 groups and fed control-(C) diet (AIN-93G), 10 g/100 g red Sorrel Meal (SM) and Sorrel Juice (SJ). All rats received 2 subcutaneous injections of azoxymethane (AOM) at 7 and 8 week and were killed using CO2 euthanasia at 17 week of age. Total phenolics (mg/100 g) as Gallic Acid Equivalents (GAE), flavonoids (mg/100 g) as Catechin Equivalents (CE) and VCAEC ranged from 256.8"1.0 to 433.7"1.4 for fresh and dry sorrel. Total number of ACF in rats fed C, SM and SJ were 154.4, 38.6 and 24.6, respectively. Sorrel is attracting the attention of food manufacturers and these results indicate that phytochemicals present in sorrel may have many possibilities for health improvement.
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How to cite this article:

M. Verghese, M. S.C. Fullerton, L. T. Walker, L. A. Shackelford, E. Cebert, J. Boateng, S. Ogutu, J. Khatiwada, M. Guyton, J. Jones and C. B. Chawan, 2008. Determination of Antioxidant Contents in Red Sorrel and its nticarcinogenic Potential in Azoxymethane-Induced Colonic Aberrant Crypt Foci. Research Journal of Phytochemistry, 2: 69-76.

DOI: 10.3923/rjphyto.2008.69.76

URL: https://scialert.net/abstract/?doi=rjphyto.2008.69.76

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